Service Details
Comprehensive Genomic DNA Services
At Gnome Sciences, we recognize the immense value of sensitivity in genomic studies, particularly when dealing with limiting sample sizes. Our currently validated assays and panels cover a broad spectrum of genes, including but not limited to APO E CYP3A4, FKBP5, MTHFR, CYP1A2, CYP3A5, GRIK4, SLCO1B1, CYP2C9, COMT, HTR2A, UGT2B15, CYP2C19, Factor 2, HTR2C, VKORC1, CYP2D6, FV Leiden, and ITGB3. If your genomic target isn’t listed, our team is ready to collaborate with you to develop a customized, validated assay tailored to your project’s unique requirements.
We offer mid-throughput (1 – 48 assays, up to 48 samples) and high-throughput options (1 – 96 assays, up to 96 samples), ensuring flexibility and scalability for your research needs.
Copy Number Analysis
Copy Number Variation (CNV) offers crucial insights into human evolution, traits, and disease. To aid in these explorations, we provide validated assays for CNV testing, like our CYP2D6 assay, or can develop custom assays that target your specific gene of interest.
Our mid-throughput option covers 1 sample across 48 genes to 48 samples across 1 gene, while our high-throughput option extends this to 1 sample across 96 genes to 96 samples across 1 gene.
Sample Identification / Fingerprinting
Ensuring sample integrity is critical to avoid wasted resources, misleading data, and potential reputational damage. To assist with this, Gnome Sciences offers cost-effective sample verification using a panel of 96 SNPs for biorepositories and research study samples. Our services can handle a throughput from 1 to 96 samples across the SNP Identity Panel.
Mutation Analysis Assays
With the increasing importance of mutation detection in studying complex diseases like cancer, our lab offers a range of PCR-based assays. We are equipped to work with various sample types, including formalin-fixed paraffin-embedded (FFPE) tissues. Our assays are highly sensitive and specific, with below 1% Limit of Detection (LOD). These include:
- PIK3CA detection for Breast, Colorectal, and Lung Cancers
- KRAS/BRAF detection for Melanoma and Colorectal Cancer
- Assays for multiple mutations associated with Leukemia and Glioblastoma
- HPV subtyping for the 14 high-risk subtypes that can persist and progress into cervical cancer
For unique requirements, we also offer the development of custom assays. Please contact us for additional information.